If you chafe in the groin area, you may want to consider the kind of underwear you’re wearing, according to Quo Active underwear founder Stacey Hunter Harrington. She says Quo underwear has sweat-wicking, and doesn’t shift around when you workout like some cotton panties will. Hunter-Harrington also advises people avoid running in clothing and underwear with many tags or seams, which can be chafing "hot spots."